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微生物所等在γ疱疹病毒侵入机制研究中获进展

2019-11-26 微生物研究所
【字体:

YUYINBOBAO

  卡波氏肉瘤相关疱疹病毒(Kaposi’s sarcoma-associated herpesvirus,KSHV)和爱泼斯坦-巴尔病毒(Epstein-Barr virus,EBV)属于γ疱疹病毒亚科,是与恶性肿瘤密切相关的人类癌症相关病毒。11月24日,中国科学院院士、中科院微生物研究所研究员高福团队在Nature Communications上在线发表了题为Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses的研究论文,分别解析了KSHV以及EBV糖蛋白gHgL与其共同受体EphA2的复合物晶体结构,揭示了这两种感染人γ疱疹病毒利用gHgL结合受体EphA2的分子机制,并提供了EphA2可能作为γ疱疹病毒通用受体的证据,暗示了其他γ疱疹病毒有跨种传播的风险。

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