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心理所等通过定量脊髓磁共振成像评估中枢神经系统脱髓鞘疾病

2019-11-25 心理研究所
【字体:

YUYINBOBAO

BG视讯网  ZHONGSHUSHENJINGXITONGTUOSUIQIAOJIBING(demyelinating central nervous system disease)SHIYIZHONGZISHENMIANYIXITONGJIBING,LINCHUANGJIAOCHANGJIANDELEIXINGSHIYIZHONGBINGYINBUMINGDETXIBAOZHUDAOMIANYIJIBING——DUOFAXINGYINGHUAZHENG(multiple sclerosis,MS)。JINNIANLAI,YOUSHUITONGDAODANBAI-4KANGTI(aquaporin-4 antibody,XIAWENJIANCHENGAQP4-Ab)YINQIDEJIFAXINGTUOSUIQIAOJIBINGSHISHENJINGJISUIYANPUXIZHANGAIYIJIYOUSUIQIAOSHAOTUJIAOZHIXIBAOTANGDANBAIKANGTI(myelin oligodendrocyte glycoprotein antibody,XIAWENJIANCHENGMOG-Ab)YINQIDEYUANFAXINGTUOSUIQIAOJIBINGYEZAILINCHUANGSHANGSHOUDAOGENGDUOGUANZHU。

BG视讯网  MOG-AbJIBING、AQP4-AbJIBINGHEDUOFAXINGYINGHUAZHENGSUIJUYOUYIDINGDELINCHUANGXIANGSIXING,DANYEYOUGEZIDUTEDEFABINGJILIHELINCHUANGBIAOZHENG。LEJIEQUDONGZHEIXIECHAYICHUXIANDEYINSU,KEGENGSHENRUDILIJIEZHEIXIEJIBING,CONGERGENGHAODIKAIZHANZAOQIZHENDUAN、ZHILIAOFANGANYOUHUAHEYUHOUJIANCE。JISUIBINGBIANSHIZHEISANZHONGJIBINGGONGYOUDEBIAOZHI,TAKENENGSHIXUDUOLINCHUANGBIAOZHENG(TEBIESHIZHITICANJIHESHENJINGBINGLIXINGTENGTONGDENG)DEZHUYAOCHENGYIN。JISUICIGONGZHENCHENGXIANGWEIFEIQINRUSHIYANJIUJISUIBINGBIANTIGONGKENENG,DANZAIZHEIZHONGTIJIJIAOXIAOQIEBUDUANSUISHENGLIJIELVYIDONGDEJIEGOUSHANGCHENGXIANG,JUYOUJISHUTIAOZHANXING。

  11月18日,中国科学院心理研究所行为科学重点实验室研究员孔亚卓和牛津大学临床神经科学系教授Jacqueline Palace团队在Brain上,在线发表题为Quantitative Spinal Cord MRI in MOG-Antibody Disease,Neuromyelitis Optica and Multiple SclerosisBG视讯网的研究论文。该研究为单中心临床磁共振成像研究,运用多模态定量脊髓磁共振成像(quantitative spinal cord MRI)技术,招募多发性硬化症患者、MOG-Ab疾病患者、AQP4-Ab疾病患者和健康志愿者共80人,获取其颈部等区域脊髓的截面积、病灶分布、纤维束各向异性分数和磁转化率等定量指标(图1),用于区分三种中枢神经系统脱髓鞘疾病,并评估其与残疾指数和病理性疼痛等临床指标的关联性。

  YANJIUYUNYONGZHUCHENGFENFENXIFANGFACESHILEJISUICHENGXIANGDINGLIANGZHIBIAODUIJIBINGLEIXINGDEFENBIANHEYUCENENGLI,JIEGUOFAXIAN,JISUICIGONGZHENCHENGXIANGDINGLIANGZHIBIAOKEQUFENCHUSANZHONGZHONGSHUSHENJINGXITONGTUOSUIQIAOJIBING(TU2)。GAIYANJIUTONGGUOBIJIAOJISUICHENGXIANGDINGLIANGZHIBIAOYULINCHUANGZHIBIAODEGUANXI,FAXIANJISUIDEJIEGOUWEISUOYUHUANZHEDECANJIZHISHUXIANGGUANZUIXIANZHU,SHUOMINGJISUIJIEGOUSUNSHANGKENENGSHITUOSUIQIAOJIBINGZHICANDEZHUYAOYINSU。TONGSHI,TONGGUODUOZHONGHUIGUIMOXING,YANJIUFAXIANJISUIQIUNAOSHUDEFAZHIYUHUANZHEDESHENJINGBINGLIXINGTENGTONGPINGFENCHENGXIANZHUFUXIANGGUAN。JISUIQIUNAOSHUWEIYUJISUIBAIZHIZHONG,YOUJISUICESUOHEJISUIQIANSUOLIANGBUFENZUCHENG,SHIGANJUEXINXIYOUJISUISHANGXINGCHUANDIZHIDANAODEZHONGYAOTONGLU,GAIJIEGUOJINYIBUZHENGMING,GANJUESHANGXINGTONGLU——JISUIQIUNAOSHUDESUNSHANGKENENGSHITUOSUIQIAOJIBINGBANFASHENJINGBINGLIXINGTENGTONGDEZHONGYAOYINSU。JIYUGAIYANJIUJIEGUO,JISUIMISANZHANGLIANGCHENGXIANGDEBAIZHIXIANWEISHUFENXIYOUWANGCHENGWEISHENJINGBINGLIXINGTENGTONGYANJIUDEYOUXIAOGONGJU。MOG-AbSHIXINDINGXINGDEJIBING,XIANGGUANYANJIUJIAOSHAO,QISHIFOUHUIDUIZHONGSHUSHENJINGXITONGDEHUIZHIJIEGOUCHANSHENGYINGXIANGSHANGXUTANSUO。YANJIUFAXIAN,MOG-AbJIBINGHUANZHEJISUIHUIZHITIJIJIANXIAO,QIEDANXIANGHEFUFAXINGMOG-AbJIBINGHUANZHEDEJISUIHUIZHITIJICUNZAIXIANZHUCHAYI。ZHEIYIFAXIANWEIMOG-AbJIBINGHUANZHEHUIZHIJIEGOUSHOUSUNTIGONGDIYIGEDINGLIANGZHIBIAOZHENGJU,BINGZHENGMINGCHUXIANFUFAGUOCHENGHUANZHEDEHUIZHISHOUSUNGENGWEIYANZHONG,DUIYULINCHUANGZHILIAOJUYOUCANKAOJIAZHI。

  MUQIAN,DANAOCIGONGZHENCHENGXIANGHEFENXIJISHUYIXIANGDUICHENGSHU,DANSHIJISUICIGONGZHENCHENGXIANGRENGMIANLINTIAOZHAN。JISUICIGONGZHENCHENGXIANGZUOWEIKAIZHANJISUIJIEGOUHEGONGNENGYANJIUDEFEIQINRUXINGYANJIUJISHU,KEYIWEIJISUIJIBINGDEFASHENG、FAZHANHEYUHOUTIGONGGENGJIAJUTIHEDINGLIANGHUADESHENGLIZHIBIAO,DUIYUJICHUYANJIUHELINCHUANGYINGYONGJUNYOUZHONGYAOYIYI。SUIZHECHENGXIANGJISHUDEGAIJINJIFENXILIUCHENGDEKAIFA,JISUICIGONGZHENCHENGXIANGZAIRENTIGANJUE、YUNDONGDENGJICHUKEXUEYANJIU,YIJIJISUISUNSHANG、JISUIYAN、DUOFAXINGYINGHUAZHENG、JIWEISUOXINGCESUOYINGHUAZHENGHEMANXINGTENGTONGDENGJIBINGDELINCHUANGYINGYONGZHONGZHUJIANDEDAOTUIGUANGSHIYONG。

BG视讯网  KONGYAZHUOHEJacqueline PalaceWEILUNWENGONGTONGTONGXUNZUOZHE,YANJIUGONGZUODEDAOGUOJIAZIRANKEXUEJIJINXIANGMUHEZHONGKEYUAN“KEYANXINXIHUAYINGYONGGONGCHENG”XIANGMUDENGDEZIZHU。

   

 

  TU1.(A)JISUIJIEGOUFENGESHIYI(B)GEXIANGYIXINGFENSHU(FA)TU、JISUIQIUNAOSHU(HONGSE)HEPICENGJISUISHU(LVSE)(C)CIZHUANHUATUXIANGFENGE(D)T2* ZHOUWEITU,XIANSHIHUIZHIHEBINGZAO(E)HUIZHIFENGE(F)BINGZAOFENGE(G)BINGZAOPEIZHUNDAOT2JIEGOUXIANG

TU2.TONGGUOZHENGJIAOPIANZUIXIAOERCHENGMOXINGDECHUDEYUCEJIEGUO: (A)MOG-AbJIBINGYUDUOFAXINGYINGHUAZHENG(B)MOG-AbJIBINGYUAQP4-AbJIBING(C)AQP4-AbJIBINGYUDUOFAXINGYINGHUAZHENG

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